TY  -  JOUR
AU  -  Pompili, Maurizio
AU  -  Rihmer, Zoltan
AU  -  Gonda, Xenia
AU  -  Serafini, Gianluca
AU  -  Sher, Leo
AU  -  Girardi, Paolo
T1  -  Early onset of action and sleep-improving effect are crucial 
in decreasing suicide risk: the role of quetiapine XR in the treatment of unipolar and bipolar depression
PY  -  2012
Y1  -  2012-11-01
DO  -  10.1708/1183.13092
JO  -  Rivista di Psichiatria
JA  -  Riv Psichiatr
VL  -  47
IS  -  6
SP  -  489
EP  -  497
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-2502
Y2  -  2026/05/21
UR  -  http://dx.doi.org/10.1708/1183.13092
N2  -  SUMMARY. Although the possibilities of antidepressive pharmacotherapy are continuously improving, the rate of nonresponders or partial responders is still relatively high. Suicidal behavior, the most tragic consequence of untreated or unsuccessfully treated depression, commonly observed in the first few weeks of antidepressive treatment before the onset of therapeutic action, is strongly related to certain symptoms of depression like insomnia. The present paper reviews the newly discovered and well-documented antidepressive effect of quetiapine in bipolar and unipolar depression with special focus on its early onset of action and its sleep-improving effects. Both beneficial effects play an important role in the reduction of suicidal risk frequently observed in depressed patients.
ER  -