TY  -  JOUR
AU  -  Parnanzone, Serena
AU  -  Serrone, Dario
AU  -  Rossetti, Maria Cristina
AU  -  D'Onofrio, Simona
AU  -  Splendiani, Alessandra
AU  -  Micelli, Valeria
AU  -  Rossi, Alessandro
AU  -  Pacitti, Francesca
T1  -  Alterations of cerebral white matter structure in psychosis and their clinical correlations: a systematic review of Diffusion Tensor 
Imaging studies
PY  -  2017
Y1  -  2017-03-01
DO  -  10.1708/2679.27441
JO  -  Rivista di Psichiatria
JA  -  Riv Psichiatr
VL  -  52
IS  -  2
SP  -  49
EP  -  66
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-2502
Y2  -  2026/05/19
UR  -  http://dx.doi.org/10.1708/2679.27441
N2  -  SUMMARY. Schizophrenia is a common, severe and chronically disabling mental illness. Most of MRI studies in schizophrenia suggest the involvement of white matter (WM) pathology in multiple cerebral regions in the neurobiology of this condition. White matter fiber tracts connecting numerous cortical regions have been the focus of a number of studies using a magnetic resonance technique called “Diffusion Tensor Imaging” (DTI). A literature search of published DTI studies was conducted using the major database National Centre for Biotechnology information (NCBI) PubMed (MEDLINE). Our review covers 95 published papers. We summarise the main DTI findings involving the different brain regions in patients affected by or at high-risk for psychosis; we discuss clinical implications of these white matter disruptions and the limitations of current studies, listing the potential confounds and suggesting potential future research directions.
ER  -