TY  -  JOUR
AU  -  Cosci, Fiammetta
AU  -  Chouinard, Guy
AU  -  Chouinard, Virginie-Anne
AU  -  Fava, Giovanni Andrea
T1  -  The Diagnostic clinical Interview for Drug Withdrawal 1 (DID-W1) – 
New Symptoms of Selective Serotonin Reuptake Inhibitors (SSRI) 
or Serotonin Norepinephrine Reuptake Inhibitors (SNRI): 
inter-rater reliability
PY  -  2018
Y1  -  2018-03-01
DO  -  10.1708/2891.29158
JO  -  Rivista di Psichiatria
JA  -  Riv Psichiatr
VL  -  53
IS  -  2
SP  -  95
EP  -  99
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-2502
Y2  -  2026/04/28
UR  -  http://dx.doi.org/10.1708/2891.29158
N2  -  SUMMARY. Aim. A wide range of clinical phenomena have been reported with dose reduction or drug discontinuation of Selective Serotonin Reuptake Inhibitors (SSRIs) or Serotonin Norepinephrine Reuptake Inhibitors (SNRIs). In 2015, a new classification of SSRIs/SNRIs withdrawal (i.e., new withdrawal symptoms, rebound symptoms withdrawal, persistent post-withdrawal disorders) was outlined on the basis of the literature and clinical observations. A semistructured clinical interview, the Diagnostic clinical Interview for Drug Withdrawal 1 - New Symptoms of SSRI and SNRI (DID-W1), was developed for identifying and differentiating such syndromes. Its inter-rater reliability has been tested. Methods. Seventeen consecutive outpatients with a history of SSRI or SNRI dose reduction or discontinuation were assessed independently by 2 clinicians at different times during the same day. Percent agreement, Cohen’s kappa, and the squared correlation coefficient were used to measure inter-rater reliability. Results. The percent agreement for the whole interview was 97.06%, the Cohen’s kappa 0.85 (95% CI of 0.61-1.08), the squared correlation coefficient 0.72. Discussion and conclusions. The kappa values indicated excellent inter-rater agreement. Validity evaluation and comparison with other instruments need to be performed. The DID-W1 may help diagnosing the clinical phenomena related to SSRI and SNRI discontinuation, their differentiation from relapse, and the potential iatrogenic origin of psychiatric symptoms in clinical practice.
ER  -