TY  -  JOUR
AU  -  Ciafrè, Stefania
AU  -  Ferraguti, Giampiero
AU  -  Tirassa, Paola
AU  -  Iannitelli, Angela
AU  -  Ralli, Massimo
AU  -  Greco, Antonio
AU  -  Chaldakov, George N.
AU  -  Rosso, Pamela
AU  -  Fico, Elena
AU  -  Messina, Marisa Patrizia
AU  -  Carito, Valentina
AU  -  Tarani, Luigi
AU  -  Ceccanti, Mauro
AU  -  Fiore, Marco
T1  -  Nerve growth factor in the psychiatric brain
PY  -  2020
Y1  -  2020-01-01
DO  -  10.1708/3301.32713
JO  -  Rivista di Psichiatria
JA  -  Riv Psichiatr
VL  -  55
IS  -  1
SP  -  4
EP  -  15
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-2502
Y2  -  2026/05/20
UR  -  http://dx.doi.org/10.1708/3301.32713
N2  -  SUMMARY. The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a large number of physiological mechanisms that result in neurotrophic, metabotrophic and/or immunotrophic effects. Neurodegenerative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infection have in common the effect of changing the brain levels of neurotrophins, in particular NGF. The contribution of both NGF and its receptor TrkA in such events and the recent promising results of NGF based therapies are here presented and discussed.
ER  -