TY  -  JOUR
AU  -  Lazzari, Carlo
AU  -  Rabottini, Marco
T1  -  Biopsychosocial theories of borderline personality disorder: a meta-synthesis and psychopathological network model from a systematic review
PY  -  2023
Y1  -  2023-11-01
DO  -  10.1708/4143.41406
JO  -  Rivista di Psichiatria
JA  -  Riv Psichiatr
VL  -  58
IS  -  6
SP  -  258
EP  -  270
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-2502
Y2  -  2026/05/03
UR  -  http://dx.doi.org/10.1708/4143.41406
N2  -  Summary. Background. Borderline personality disorder (BPD) is a complex mental health condition with an altered image of self, impulsive acts, suicidal ideation, and self-harm requiring intensive care in outpatient and inpatient settings. The biopsychosocial (BPS) model adopted in the current study extracted the outcomes of a research about the diagnosis, causes and treatment of BPD. A network model helped link these results in a unitary model with applications in clinical practice for assessment and intervention. Methods. We conducted a literature review of current studies on the BPS causes of BPD and merged them through meta-synthesis. The results were then elaborated with a psychopathological network analysis for linking the extracted factors with higher degree of centrality in the network and merged in a final comprehensive model. Results. The theoretical modelisation suggests that BPS causes merged with the diathesis-stress model persistently activate the cortico-limbic system and prefrontal cortex, induce neuroinflammation, and stimulate suicidal and parasuicidal ideation and behaviours modulated by psychological and pharmacological treatment. Conclusions. Using a network model in psychopathology allowed the merging of data about BPD into a unitary and dynamic pattern which can be helpful to direct assessments and interventions in clinical practice.
ER  -