TY  -  JOUR
AU  -  Syamsuddin, Saidah
AU  -  Firdaus
AU  -  Limoa, Erlyn
AU  -  Idris, Irfan
AU  -  Lisal, Sonny Teddy
T1  -  Effect of Ajwa dates adjuvant therapy on improvement of clinical symptoms and serum interleukin-1β (IL-1β) levels in schizophrenia patients
PY  -  2025
Y1  -  2025-09-01
DO  -  10.1708/4583.45902
JO  -  Rivista di Psichiatria
JA  -  Riv Psichiatr
VL  -  60
IS  -  5
SP  -  202
EP  -  213
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-2502
Y2  -  2026/04/29
UR  -  http://dx.doi.org/10.1708/4583.45902
N2  -  Summary. Background. Inflammation plays a role in the etiology and pathophysiology of schizophrenia symptoms, through the effects of proinflammatory cytokines such as IL-1β. Ajwa dates are one of the non-pharmacological modalities that have anti-inflammatory and antioxidant properties. However, clinical trials are still limited in exploring the role of Ajwa dates as an adjuvant in the management of schizophrenia. Objective. To determine the effect of Ajwa dates adjuvant therapy on the improvement of clinical symptoms and serum IL-1β levels in schizophrenia patients. As well as determining the correlation between clinical symptoms and serum IL-1β levels. Methods. Quasi-experimental study with random group selection using a single blind method. The number of subjects was 60, divided into a treatment group that received risperidone 4-6 mg/day plus 7 Ajwa dates/day for 8 weeks and a control group that only received risperidone. Improvement of clinical symptoms was assessed using the PANSS score, and serum IL-1β levels were measured in the first week (baseline) and week 8, with enzyme-linked immunoassay. Results. The better improvement in clinical symptoms was observed in the treatment group. A significant decrease in serum IL-1β levels was observed in both groups after 8 weeks of therapy, but the treatment group showed a greater decrease compared to the control group. A significant correlation was found between the improvement of positive symptoms and general psychopathology symptoms with a decrease in serum IL-1β levels in the treatment group. Conclusions. Ajwa dates have an adjuvant effect on improving clinical symptoms and reducing serum IL-1β levels through their anti-inflammatory properties in schizophrenia patients receiving risperidone therapy.
ER  -